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In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum MECI on programmed cell death in the testicular damage resulting from streptozotocin STZ induced diabetes in rats.
Blood glucose were checked in diabetic induced animals. At the end of the study, all animals were sacrificed. Testis tissues were collected for the assessment of sperm parameters, and for biochemical and histopathological analysis.
The MECI-treated rats in the diabetic group showed an improved blood sugar, histological appearance, sperm parameters and program cell death. Every disease has a cure, according to traditional beliefs.
Diabetes is a chronic non-communicable disease exposes the limitations of biomedical medicine and motivates people who subscribe to these widely held beliefs to turn to traditional healers. Traditional medicine refers to practices and approaches that apply — separately or in combination — plant- animal- and mineral-based medicines, spiritual therapies, manual techniques and exercises to diagnose, prevent and treat illnesses, or maintain or enhance well-being.
|Kallistem- Preservation of male fertility and treatment of male infertility||Toxicant Exposures in Rhode Island: Past, Present, and Future Project 1:|
|Project 1: Molecular Biomarkers for Assessing Testicular Toxicity | Superfund Research Program||The information in this profile may be out-of-date. It was last revised in|
|EXTOXNET PIP - BENOMYL||Soluble in acetic acid and dimethyl-formamide Water, pH 4: Stable in acidic and alkaline solutions at room temperature and when exposed to light.|
Millions of people around the world use traditional medicine to help meet some of their primary healthcare needs. Diabetes mellitus DM is a degenerative disease. Alteration of carbohydrate metabolism occure in diabetes, that affects male reproductive function at multiple levels 2, 3.
Lastly it causes impairing penile erection and ejaculation. In diabetes, infertility is a common complication in diabetic men and experimental2, 3, 4, 5, 6. Due to oxidative stress and peroxidative damage are believed to be the most influential harm causing factors in infertility of diabetic patients.
In insulin-dependent diabetes mellitus type 1 diabetes mellitus - DM in both humans and animals lead to decrease of testicular weight, structural and ultrastructural changes in the spermatogenic process.
These changes are mainly due to the loss of germ cells by apoptotic cell death, low testosterone and lack of insulin 7, 8. In diabetic animals, histopathological and histomorphometric alterations occure in seminiferous tubules 9, Diabetes increases apoptosis in testicular germ cells either in mice or rats The primitive man used herbs as therapeutic agents and medicament, which they were able to procure easily 8.
Recent discovery and advancement in medicinal and aromatic plants have lead to the enhancement of health care of mankind. Clerodendrum infortunatum family- Lamiaceae having different pharmacological activities such as antimicrobial, anthelmintic, hepatoprotective, anticonvulsant, wound healing, analgesic activities of their different parts.
The treatment effects of C. Therefore, this study was performed to determine the treatment effects of methanolic extract of Clerodendrum infortunatum leaves on histopathological alteration of seminiferous tubules in streptozotocin-induced diabetic rats.
A voucher specimen of each of the collected samples was deposited in the institutional herbarium for future reference. Preparation of extracts by hot extraction: After initial defatting with methanol, successive hot extraction in a soxhlet apparatus at a temperature not exceeding 70 deg C were carried out.
Then the extract obtained had been filtered and trated at reduced temperature on a rotary vacuum evaporator and concen stored at 4 deg C until further use.
The yield was found to be around 7. Dried extracts MECI were kept in refrigerator and used for further study. Healthy young Albino rats weighing between g to g were procured from Indian Institute of Cultivation of science, Kolkata.
The animals were fed with Pellet chew feed standard diet and water ad libitum.The present study has investigated the role of benomyl (BNL) vs carbendazim (CBZ) in BNL-induced testicular toxicity.
Equivalent molar concentrations of BNL and CBZ were administered to rats intraperitoneally ( μmol/kg) or by direct injection into the testis ( μmol/testis). The role of the benomyl metabolite carbendazim in benomyl-induced testicular toxicity.
Evaluation of carbendazim for gene mutations in the Salmonella /Ames plate-incorporation assay: the role of aminophenazine impurities . Acute Chemotherapy-Induced Cardiovascular Changes in Patients With Testicular Cancer Chemotherapy-induced vascular toxicity may not only result in acute cardiovascular complications during treatment, but may also be involved in the initiation and progression of atherosclerosis and the increased risk of vascular events after long .
Carbendazim [methylbenzimidazole carbamate, MBC (CBZ)], a metabolite of benomyl is one of the most widespread environmental contaminants of major concern to human and animal health. The protective effect of resveratrol (RSV), vitamin E (E) and a combination of both on carbendazim-induced toxicity was investigated using haematology, serum biochemistry and histopathology in male Wistar .
The results presented here provide evidence of significant testicular alterations mediated by the administration of caffeine, cocaine and their combination, and highlight a potential role of the local dopaminergic system in testicular toxicity induced by psychostimulants.
Carbendazim-induced occlusions of the ductuli efferentes in the adult rat' Total Time (h) Number Number Total Location of occlusions' after of of Number % treatment animals ductules occluded occluded' Proximal junction Conus Terminus 12 5 33 25 13 5 12 0 24 5 32 27 16 3 11 0 1 mg kg-' by single oral gavage.